EXPERIMENTAL SUBSTANTIATION OF TREATMENTAND- PROPHYLACTIC MEASURES OF SUPPORT OF COMPLEX DENTAL TREATMENT OF TEENAGE ATHLETES AT MODELING OF CALCIUM AND PROTEIN DEFICIENCY

Abstract

Purpose of the work. Experimental study of the effect of the developed therapy accompanying dental treatment of adolescent athletes on the biochemical parameters of blood serum, bone tissue, oral mucosa, and liver of rats in conditions of calcium and protein deficiency. Materials and methods. Experimental studies were conducted on 28 male rats aged 1 month of the Wistar herd breeding line with an average weight of 49.7 G at the beginning of the experiment. The animals were divided into groups: 1-intact, n=9 (standard vivarium diet); 2-diet deficient in calcium and protein (DKB), n=10 (corn-68.9%, beetroot – 20.7 %, cabbage-10.4 %); 3-DKB + therapeutic and preventive complex, n=9 (in the morning they brushed their teeth with meridol toothpaste – 50-55 mg per rat, fed a diet, and in the evening – a complex). The use of a treatmentand- prophylactic complex, which included «Chlorophyll- Spray», «Active Sulfur», «Active Fluorine», «INOS» and «Albumin Egg Plus», in conditions of calcium and protein deficiency allowed to normalize the activity of alanine aminotransferate in serum rats alkaline phosphatase, triglycerides, total cholesterol, total protein and calcium, in the bone tissue of the jaws to reduce the degree of atrophy of the alveolar process and the intensity of the carious process, to bring to normal the activity of alkaline and acidic phosphatases, the level of malonic dialdehyde, acid phosphatase, elastase, catalase, lysozyme, urease activity, degree of dysbiosis and antioxidant-prooxidant index, and in liver homogenates – urease, elastase, alkaline and acid phosphatase activity. The results obtained indicate a pronounced immunostimulatory, anti-inflammatory, antimicrobial, antioxidant, cariesprophylactic, periodontal-protective and antidisbiotic effect of the proposed therapy.