DYNAMICS OF CIRCULATING IMMUNE COMPLEXES IN THE BLOOD OF PATIENTS WITH GENERALIZED PERIODONTITIS ACCOMPANIED BY DIFFERENT REACTIVITY OF THE ORGANISM
DOI:
https://doi.org/10.35220/2078-8916-2021-42-4.6Keywords:
generalized periodontitis, circulating immune complexes, reactivity of the organismAbstract
Purpose of the study is to study the dynamics of circulating immune complexes of different the sizes (mCIC, cCIC, vCIC) in the blood of patients with generalized periodontitis accompanied by normo-, hyper- and hyporeactivity of the body after patch surgery. Materials and methods of research. 216 patients (82 men and 134 women), aged between 45 and 55 years old, with the diagnosis of generalized periodontitis of II, III degree of severity, chronic course were examined. Depending on the condition of reactivity of the body, patients were divided into three groups: 1) patients with normoreaction (132 persons, 61%); 2) patients with hyperreaction (46 persons, 21%); 3) patients with hyporeaction (38 persons, 18%). Patients with generalized periodontitis of II, III degrees of severity after initial therapy, underwent patch surgery according to the indications. Blood sampling was performed after surgery on the 1st, 4th, 6th and 9th day from the ulnar vein with a volume of 10 ml in the morning on an empty stomach. The content of circulating immune complexes was determined by radioimmunoassay using the test kits. Scientific novelty. The condition of patients with generalized periodontitis accompanied by normoreactivity of the body after surgery is characterized by tension of the general (at the level of the circulating immune complexes of all the sizes in the blood) immunity with normalization by the end of the observation. The dynamics of the content of the circulating immune complexes of different masses with normoreactivity of the organism had a qualitatively identical picture and was characterized by their increase with its maximum on the 6th day. By the end of the observations, the content of all the groups of circulating immune complexes returned to its baseline (p>0,05). The patients with generalized periodontitis, accompanied by hyperreactivity of the body, have a dysfunction of general immunity which is caused by depletion of protective and compensatory capabilities, that is manifested by pronounced fluctuations of the circulating immune complexes in the blood with their imbalance by the end of observations. During the entire observation period the level of all the studied CICs was significantly higher compared to the initial values, and with such values which are typical for normoreactivity (p<0,05). The patients with generalized periodontitis accompanied by hyporeactivity of the body suffer from the dysfunction of the general immunity because of the reduced functional activity of protective factors, manifested by a later rise and relatively low amplitude of changes in circulating immune complexes of different sizes. On the 9th day, the content of CICs in the blood of patients in this group was intermediate in value: higher than in cases of normoreactivity of the body and lower than in cases of hyperreactivity. Conclusions. Correction of altered parameters in patients with generalized periodontitis with impaired reactivity of the body with bringing them to values which are typical for normoreactivity is considered to be a condition for optimization and stabilization of the process in periodontal tissues.
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