THE CYTOMORPHOLOGICAL EVALUATION OF THE EFFECTIVENESS OF TREATMENT OF GENERALIZED PERIODONTITIS IN PATIENTS WITH DUODENAL ULCER

Abstract

Abstract. The problem of criteria for the appropriate choice of tactics for the treatment of periodontal diseases in their delineation for specific clinical situations, taking into account the systemic status of patients and the conditions of real practice remains indefinite. Therefore, the analysis of the appointment of alternative treatment models for patients with generalized periodontitis is relevant. The purpose of the study іs the substantiation of the clinical efficiency of use of ozone therapy in the complex treatment of generalized periodontitis in patients with complicated duodenal ulcer. Material and methods. Complex treatment of generalized periodontitis with our proposed method of step therapy was performed in 53 patients with duodenal ulcer, complicated by bleeding (32 patients) and perforation (21 patients), Ozonation of distilled water was performed in the device Econica Bozon-KSV (Ukraine). Ozonated water was used for 3 hours after its preparation. The concentration of ozone in water was 4 mg/l. The course of ozone therapy continued 10 days. For cytomorphological study of the effectiveness of the treatment of generalized periodontitis, exfoliative material was removed from periodontal pockets after washing with isotonic sodium chloride solution. The preparations were stained by the Papenheim method. Microscopy was performed in an immersion system using eyepieces × 10 (or × 20) and a lens × 40. Results and discussion. Cytological examination revealed changes in morphological features of cytograms: the pathogenic microflora decreases quantitatively by the 3rd day of ozone therapy or disappears by the 5th day in some patients, especially with II, I and the initial degree of severity of generalized periodontitis; the number of neutrophils remains unchanged, especially in patients with II and III degrees, but unchanged neutrophils predominate; one of the patients on the third day had monocytes on the background of reduced microflora, including amoebae. On the 5th day the microflora almost disappeared, the amoeba was not detected. The appearance of monocytes indicated the activation of the body’s defense mechanisms. Conclusions. The scheme of complex treatment of generalized periodontitis with the use of ozone therapy developed by us provides a significant improvement in clinical indicators of treatment effectiveness. The results of cytological examination showed a positive effect of ozone therapy on the course of generalized periodontitis in patients with duodenal ulcer complicated by bleeding and perforation.