CORRECTION OF BIOCHEMICAL INDICATORS OF THE GUMS AND BLOOD SERUM OF RATS DURING THE EXPERIMENTAL SIMULATION OF PERIODONTITIS ON THE BACKGROUND OF ORTHODONTIC TOOTH MOVEMENT

Abstract

The dental-maxillary system has undergone significant changes in the course of human evolution, which have led to the development of various pathological types of bite and anomalies in the position of teeth. Currently, various types of orthodontic structures are used, in this regard, the relevance of the question of the consequences of orthodontic treatment, such as hypertrophic gingivitis, that is, the study of the causes and frequency of this disease, as well as minimizing its consequences through competent and timely treatment, is growing. In adolescents, the condition of the mucous membrane and its response to orthodontic treatment require special attention, since morphofunctional disorders caused by anomalies of the dental-maxillofacial system themselves are powerful pathogenetic factors that cause the initiation and development of inflammatory diseases, including gingivitis. Purpose of the study. Experimental assessment in rats, against the background of a model of peroxide periodontitis and orthodontic movement of teeth, changes in the biochemical parameters of gums and blood serum under the influence of developed therapeutic and preventive measures. Materials and methods of research. The following preparations "Spirulina extract" (Primaflora, Ukraine) and "Calciker" (Indoko Remedis Limited, India) were used in the experimental work. A mucozoadhesive gel for the oral cavity was prepared on the basis of spirulina. Experiments were conducted on 25 White Rats of the Wistar line (males, 5 months, weight 325 = 18 g), which were divided into 4 groups. During statistical processing of the obtained results, the computer program STATISTICA 6.1. was used to assess their reliability and measurement errors. Conclusions. In the conditions of peroxidative periodontitis and additional orthodontic tooth movement, there are intensive processes of systemic inflammation, activation of lipid peroxidation, as well as inflammation and increased contamination of opportunistic microbiota on the gums, the development of dysbiosis against the background of a decrease in antimicrobial and antioxidant protection, as well as the level of hyaluronic acid in the cavity mouth of experimental rats. Prophylactic use of the proposed drugs on the background of simulated peroxide periodontitis with additional orthodontic tooth movement had a corrective effect on changes in the gums and blood serum of animals. The most effective results were observed after the use of complex prevention. The proposed prophylactic complex effectively reduced the processes of inflammation, lipid peroxidation, the development of opportunistic microbiota, the degree of dysbiosis, stimulated nonspecific antimicrobial and antioxidant protection in the oral cavity, and maintained the normal level of hyaluronic acid in the gums.