DYNAMICS OF ANTIMICROBIAL PEPTIDES IN THE ORAL CAVITY IN INFLAMMATORY PERI-ODONTAL DISEASES AGAINST THE BACK-GROUND OF ORTHODONTIC TREATMENT
DOI:
https://doi.org/10.35220/2078-8916-2020-36-2-58-61Keywords:
chronic catarrhal gingivitis, orthodontic treatment, α-defensins, catelicidin, oral fluidAbstract
Purpose of research. Study of antimicrobial peptides of oral fluid (catelicidin and α-defensins) in patients with chronic catarrhal gingivitis in the dynamics of orthodon-tic treatment.
Materials and methods of research. During orthodontic treatment in patients with chronic catarrhal gingivitis, 34 young people aged 16 to 25 years were studied, including 21 girls (61.8 %) and 13 boys (38.2 %).
All the young people surveyed were students or students of educational institutions and sought advice and treat-ment at a dental clinic. Biochemical studies were per-formed in the patients ' oral fluid. The analysis of oral flu-id studies was performed at the beginning of orthodontic treatment and 3 and 6 months after the installation of fixed orthodontic equipment.
The results of the study and their discussion. The identi-fication of quantitative and qualitative criteria for non-specific factors of protection in the oral cavity determines adaptive processes and is an important condition for con-ducting therapeutic and preventive measures.
Conclusions. The results of the analysis of the compo-nents of non-specific resistance and local immunity in the oral cavity clearly indicate that the concentration of both α - defensins and catelicidin in the oral fluid is reduced in the examined patients with chronic catarrhal gingivitis during orthodontic treatment.
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