BONE REGENERATION DURING ELIMINATION OF THE UPPER JAW ALVEOLAR PROCESS DEFECT IN RATS WITH AUTOTRANSPLANTS OF DIFFERENT ORIGIN AND DEGREE OF ITS FILLING
DOI:
https://doi.org/10.35220/2078-8916-2020-37-3-2-10Keywords:
histological study, rats, autograft, bone graft-ing, reparative regeneration, osteogenesisAbstract
The article presents the results of the study of reparative regeneration and the course of osteogenesis in autografts of different origin after elimination of the bone defect of the alveolar process of maxilla of 60 rats with different degrees of its filling. In 2018-2019 on the territory of the Experimental Biological Clinic of Bogomolets National Medical University Ukraine, Kyiv, a group of scientists: Professor L. M. Yakovenko, graduate student M. O. Kulynych, intern O. O. Kulynych performed an experi-mental study on 60 white rats; histology and morphometry were performed in the National Institute of Surgery and Transplantology named after O. O. Shalimov of National Academy of Medical Sciences of Ukraine by Ph.D. histologist I. M. Savytska. The animals were divid-ed into two groups of 30 animals each: the first group had a complete filling of the defect of the alveolar process of maxilla with an autograft, the second one had ½. Each group was divided into two subgroups. In the first sub-group, the defect of the alveolar process of maxilla was filled with osteoplastic material taken from the tibia, in the second subgroup, it was filled with osteoplastic mate-rial taken from the submaxilla. The animals were re-moved from the experiment on the 60th, 90th, and 120th days after the surgery. Reparative regeneration in the im-plantation zone occurred more intensively in the group with the ½ filling of the bone defect. This is evidenced by the consolidation, fusion of the submaxilla autograft with the surrounding bone tissue, and the completion of the process of osteoregeneration on the 60th day. Reparative regeneration and the course of osteogenesis are more complete with the use of the submaxilla autografts. It was found that the replacement of connective tissue and the formation of bone tissue in the area of the defect is com-pleted faster when the defect is filled to ½. This method of filling can be recommended for use in clinical settings.
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