METHYLATION OF GENES PROMOTERS PARTICIPATING IN BONE METABOLISM IN DENTOFACIAL ABNORMALITIES PATIENTS ON THE BACKGROUND OF CHRONIC PERIODONTITIS AND METABOLIC SYNDROME
DOI:
https://doi.org/10.35220/2078-8916-2019-34-4-25-29Keywords:
gene methylation, bone metabolism, ortho-dontic treatment, periodontitis, metabolic syndromeAbstract
It was shown that in patients referred on orthodontic treatment with varying degrees of periodontitis on the background of metabolic syndrome, there is an increase of RANKL gene promoter methylation level in gum tis-sues in case of chronic generalized periodontitis of 2nd or 3rd degree, which indicates enhancing the resorptive function of the RANKL gene in this case. In addition, a correlation was observed (correlation coefficient 0.68) between methylation of the RANKL and INFγ gene pro-moters. The content of methylated DNA of the LEP gene in patients with chronic generalized periodontitis was significantly higher when combined with metabolic syn-drome and did not significantly differ in patients with dif-ferent degrees of chronic generalized periodontitis in ab-sence of metabolic syndrome. The results obtained should be taken into account in development of therapeutic and preventive measures to support orthodontic treatment of dentoalveolar anomalies on the background of chronic generalized periodontitis of varying severity and metabol-ic syndrome.
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