INFLUENCE OF DIFFERENT TYPES OF VIRUSES ON TUMORGENESIS. LITERATURE REVIEW
DOI:
https://doi.org/10.35220/2078-8916-2019-34-4-61-67Keywords:
oncoviruses, tumors of salivary glands, HPV, EBV, synergism of viral infectionAbstract
Introduction. Many types of viral agents that influence tumorgenesis are known today - HPV, EBV, HBV, HCV, Kaposi's Sarcoma virus, exogenous retrovirus, and oth-ers. Among the diagnostic methods for determining viral agents are PCR (polymerase chain reaction) and immunohistochemical study. The first determines the titer of the virus in the patient's blood (by the presence of anti-gen or the number of antibodies), the second the presence of the virus in the tissue biopsy. However, despite the considerable amount of scientific research on the impact of viral infection on tumor genesis, there are a small number of works devoted to systematic review of this is-sue.
The aim of the research. To study the influence of differ-ent groups of viruses on tumorgenesis based on a litera-ture review.
Research result. The analysis of the majority of literature sources showed the presence of expressed synergism be-tween different types of virus. The development of salivary gland tumors is a typical example of tumorgenesis involv-ing viral infection, in particular HPV and EBV.
Conclusion. So, among the most common oncoviruses are HPV, EBV, HBV, HCV, Kaposi's sarcoma virus. The types of viruses described have 3 types of effect on tumorgenesis – induction of genetic instability that pro-motes cellular transformation and the appearance of clones more aggressive and prone to metastasis, the re-production of tumor microenvironment that is more suita-ble for cellular invasion and spread, changes in the cellu-lar phenotype common to all oncoviruses.
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