МІКРОБІОМ РОТА У ЛЮДЕЙ РАННЬОГО ПРАЦЕЗДАТНОГО ВІКУ (15-24 РОКИ), ХВОРИХ НА ХРОНІЧНИЙ КАТАРАЛЬНИЙ ГІНГІВІТ НА ФОНІ ВПЕРШЕ ВИЯВЛЕНОГО ЦУКРОВОГО ДІАБЕТУ І ТИПУ

Abstract

The aim of the study. Establishing the taxonomic composition of the population level, qualitative and quantitative indicators of the "macroorganismmicrobiome" ecosystem of the mouth microbiota of the early working age people (15-24 years), patients with chronic catarrhal gingivitis (CCG) on the background of newly diagnosed type I diabetes. Research methods. A microbiological examination of the oral microbiome of 34 patients with CCG, aged 15-24 years, who were diagnosed with type 1 diabetes for the first time were performed. The material selected from 25 practically healthy volunteers of the same age was as the control group. Isolates were identified by morphological, tinctorial, physiological and biochemical characteristics, microecological indicators of the "macroorganism-microbiome" ecosystem were calculated according to the methods of [2]. Scientific novelty. The obtained and presented results allow to conduct further research to establish the effectiveness of domestic probiotics and antibiotics in improving the oral microbiome of in early working age people, patients with chronic catarrhal gingivitis on the background of type I diabetes. Conclusions. The taxonomic composition of the oral microbiome in early working age people, the patients with CCG, which occurs on the background of newly discovered type 1 diabetes are presented main S. aureus, S. anginosus, E. coli, M. catarrhalis, additional S. pyogenes, S. epidermidis та C. albicans and incidental microbiota. In the mouths of early working age people, patients with CCG on the background of newly diagnosed type I diabetes, the population level of the main microbiota increases: S. aureus by 83.74%, S. anginosus – by 74.57%, E. coli – by 93.00%, M. catarrhalis – by 77.58%; additional – S. pyogenes reaches a high population level of 7.81±0.24 lg CFU/ml, S. epidermidis population level increases by 20.05%, C. albicans – by 74.33%. The population level of other opportunistic taxa also increases (H. influenzae, P. aeruginosa, P. mirabilis, P. gingivalis, bacteria of the genus Bacteroides, etc.) The formation and stability of the oral microbiome in the examined persons is regulated, in addition to the factors and mechanisms of non-specific and specific immune anti-infective protection, by the dominant representatives of the main and additional microbiota – opportunistic S. aureus, S. pyogenes, S. anginosus and E. coli.