STATE OF ANTIOXIDANT SYSTEM FOR PROTECTION OF CHILDREN'S ORAL FLUID UNDER THE DEVELOPMENT OF ODONTOGENIC INFLAMMATORY PROCESS
DOI:
https://doi.org/10.35220/2078-8916-2020-36-2-88-92Keywords:
children, acute odontogenic process, antioxi-dant defense systemAbstract
Introduction. Sustainability of the natural antioxidant de-fense system is one of the key indicators of the state of homeostasis of the human body, and also ensures the functioning of protective mechanisms in the development of typical pathological processes.
The aim of the study. To analyze the antioxidant system of oral fluid protection in children with the development of odontogenic inflammatory process in the tissues of the maxillofacial area.
Materials and methods. Materials and methods of re-search. Examination of 98 children aged 7-15 years, so-matically healthy and with concomitant pathology of the thyroid gland, who had an acute odontogenic inflamma-tory process. The levels of diene conjugates, malonic al-dehyde, catalase activity, superoxide dismutase, and HC group content were determined in the children's oral flu-id. Statistical processing of the obtained data was per-formed by standard methods of variation statistics.
Research results. Indicators of peroxidation in children's oral fluid indicated an intensification of lipid peroxida-tion, in particular, the level of malonic aldehyde in-creased by 78.57 % (p <0.05), diene conjugates - by 27.27 %. A decrease in superoxide dismutase activity and a sharp inactivation of catalase were found, which led to an avalanche-like increase in the number of free radicals in the tissues of the maxillofacial area with increased free radical oxidation.
Conclusion. The development of complex maladaptive mechanisms in the middle of the system of antioxidant protection with insufficiency of both antiperoxide and an-tiradical components is established.
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