DYNAMICS OF IMMUNOLOGICAL PARAMETERS IN THE ORAL FLUID AFTER THE PROPOSED DRUG CORRECTION IN PATIENTS WITH GENERALIZED PERIODONTITIS WITH DIFFERENT BODY REACTIVITY

Abstract

The purpose of the study. To study the dynamics of lysozyme, β-lysine, SIgA, IgA, IgG in the oral fluid of patients with generalized periodontitis of II, III severity with normal, hyper- and hyporeactivity of the body after the proposed differential drug correction. Materials and methods of research. 216 patients aged 45 between 55 years with the diagnosis of generalized periodontitis of II, III degrees of severity were examined. Depending on the condition of body reactivity, patients were divided into three groups: the first was made up of patients with normoreaction (61%); the second group consisted of people with hyperreaction (21%); the third included patients with hyporeaction (18%). All patients underwent comprehensive treatment of periodontitis according to the generally accepted methodology. Patients in the main group underwent additional differential drug correction after flap surgery. The content of immunoglobulins SgA, IgA, IgG in the oral fluid was evaluated on days 1, 4, 6 and 9. Scientific novelty. It has been established that in hyper- and hyporeactivity of the body in patients with generalized periodontitis there is a dysfunction of local immunity parameters: significant activation in hyperreaction and slow involution of elevated values in hyporeaction. Patients with generalized periodontitis of II, III degrees of severity with normal body reactivity after surgical treatment should not be prescribed drug immunocorrective correction, since the studied indicators of local immunity did not change significantly (p>0.05). In patients with hyper- and hyporesponsiveness, who underwent the proposed medical correction, on days 4-6, the dynamics of lysozyme, β-lysine, SIgA, IgA, IgG in the oral fluid was similar to that of normal reactivity. The subsequent (on the 9th day) return of the studied parameters in the oral fluid to their initial values indicates the normalization of the state of local immunity of the oral cavity (p < 0.05). Conclusions. Bringing the indicators of local immunity of the oral cavity after the proposed drug correction to those with normal body reactivity in patients with generalized periodontitis of the II and III degrees of severity is a condition for further stabilization of the pathological process in periodontal tissues.