PATHOGENETIC SUBSTANTIATION OF THE APPLICATION OF THE I-PRF TECHNIQUE IN THE TREATMENT OF GENERALIZED PERIODONTITIS ACCORDING TO THE RESEARCH DATA OF THE SCIENTIFIC LITERATURE

Abstract

The purpose of the study. To conduct an analysis of modern literary data on the necessity and expediency of the PRF technique for the treatment of generalized traumatic periodontitis of a chronic course. The study of supra (hyper) contacts and the presence of traumatic occlusion can support the initiation of chronic inflammation in the marginal periodontium against the background of a violation of the barrier function of epithelial attachment and a widespread violation of microcirculation. Local antibacterial treatment, professional hygiene of the oral cavity only temporarily relieves the symptoms of inflammation. In this regard, research is needed to determine the capabilities of autoimmune competent cells that have immunocorrelative abilities to support the local immune status in the periodontium. This is a brief review of the literature on the use of immunocompetent cells – platelets as key regulators of inflammation and immunoregulatory factors within vascular homeostasis to support local immune status. An up-to-date pathophysiological assessment of the use of PRF and i-PRF techniques, platelet growth factors for the creation of type I collagen, which plays a leading role in repair, is given. A current pathophysiological assessment of the stagnation of PRF and i-PRF techniques, platelet growth factors for the creation of type I collagen, which plays a leading role in repair, is given. It is appreciated that macrophages in the midst of inflammation play a special role in vibrating growth factors, such as plateletderived growth factor (PDGF), transforming endothelial growth factor (TGF), which also mediates chemotaxis to stimulate angiogenesis. It was found that i-PRF can sense the functional differentiation of cells similar to osteoblasts, lower blood cells. The i-PRF culture infuses the production of primary human osteoblasts before proliferation, differentiation, mineralization of adhesion teams and migration. When administered regularly, PRF and i-PRF induce a three-fold increase in human osteoblasts and proliferation processes. A negative impact on cell vitality, metabolic activity and cell migration is prevented if the i-PRF concentration exceeds 60%. These studies concern a clinically significant topic related to the treatment of chronic periodontitis and obtained by non-surgical methods of regenerative processes in the periodontal complex, which is important for the clinical practice of dentists.