INFLUENCE OF SOMATIC PATHOLOGY ON THE DEVELOPMENT OF INFLAMMATORY GUM DISEASE IN CHILDREN
DOI:
https://doi.org/10.35220/2078-8916-2024-54-4.33Keywords:
periodontium, gingivitis, microflora, salivary glycoproteins, nitric oxide, somatic diseases, immunityAbstract
Inflammatory gum disease in children with somatic diseases is associated with activation of microflora against the background of changes in the composition and properties of oral fluid, depletion of the antioxidant defense system, changes in the morphological and functional properties of the gingival epithelium. Reduced cell proliferation and maturation, increased dystrophic processes in epithelial cells disrupt the barrier function of the gums, which is one of the important links in the pathogenesis of dental pathology. Somatic diseases change the immunobiological reactivity of the body, reduce the protective and adaptive reactions that ensure the resistance of the whole organism and periodontium. In children with inflammatory periodontal diseases, changes in the relative and absolute number of T- and B-lymphocytes are observed, the content of circulating immune complexes, IgG and IgM is increased against the background of a decrease in IgA levels, and the phagocytic activity of neutrophils in peripheral venous blood is increased. In many cases, treatment measures for comorbidity are ineffective and do not stop pathological changes in the periodontium. It is necessary to know the internal and external factors that can lead to the onset and further progression of inflammatory periodontal disease, as well as to take into account which of these factors have a significant impact on the development of the disease. Purpose of the work. To determine the peculiarities of the development of inflammatory gum disease in children with concomitant somatic pathology based on the data of modern scientific research. Materials and methods of the study. We analyzed the publications of Web of Science, SpringerOpen, Structure (NCBI), HINARI, PudMed, Scopus databases using a combination of keywords: “periodontium”, “gingivitis”, “microflora”, “salivary glycoproteins”, “nitric oxide”, “somatic diseases”, “immunity”. Search criteria by year – 2014-2024. Conclusions. Тhe results obtained showed that inflammatory gum disease in children with somatic diseases has a complex chain of interrelated processes leading to a violation of the protective mechanisms of the oral cavity and periodontium against the background of a decrease in the overall resistance of the body
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