INFLUENCE OF COMPLEX MEDICAL AND PREVENTIVE ACTIVITIES ON BIOCHEMICAL PARAMETERS OF RAT BLOOD SERUM DURING MODELING OF METABOLIC SYNDROME AND DENTAL ORTHODONTIC MOVEMENT
DOI:
https://doi.org/10.35220/2078-8916-2019-32-2-2-6Keywords:
experiment, rats, metabolic syndrome, dental ortho-dontic movement, blood serumAbstract
Studies of rat blood serum confirmed the negative effect of pro-longed alimentary excess fat in combination with dysbiosis and immunosuppression on indicators of non-specific antimicrobial and antioxidant defenses. Modeling of the metabolic syndrome led to the development of hyperglycemia, increased microbial contamination, intensification of systemic inflammation and ac-tivation of lipid peroxidation. Modeling of orthodontic treatment led to an additional decrease in the indices of nonspecific anti-microbial and antioxidant protection and a simultaneous in-crease in the intensity of lipid peroxidation. The use of a thera-peutic prophylactic complex in combination with a course of physiotherapy prevented the increase in serum levels of glucose, malonic dialdehyde, elastase and urease activity, the degree of dysbiosis and also maintained at a high level non-specific pro-tection indicators - catalase activity, antioxidant-prooxidant in-dex and lysozyme activity.
References
Grundy SM. Metabolic syndrome pandemic / SM Grundy //Arterioscler Thromb Vasc Biol. – 2008. – № 28(4). – Р. 629-636.
Проданчук А.И. Развитие заболеваний пародонта у де-тей с сахарным диабетом // Молодой ученый. – 2015. – № 11. – С. 708- 710.
Mona Aly Abbassy, Ippei Watari,Ahmed Samir Bakry et al. The Effect of Type 1 Diabetes Mellitus on the Dento Craniofacial
Complex / Mona Aly Abbassy, Ippei Watari, Ahmed Samir Bakry, Ta-kashi Ono // Type 1 Diabetes: A Guide for Children, Adolescents, Young Adults and Their Caregivers, Third Edition. – 2005. – June 7. – Р. 401-430.
Bensch L, Braem M, Van Acker K et al. Orthodontic treatment considerations in patients with diabetes mellitus / L Bensch, M Braem, K Van Acker, G Willems // American Journal of Orthodontics and Dentofacial Orthopedics. – 2003. – № 123(1). – С. 74-78.
Патент 21033 Україна МПК G09B 23/28 Спосіб моделю-вання ортодонтичного переміщення зубів щурів / Горохівський В.Н. Мірчук Б.М., Дєньга О.В.; опубл.15.02.2007, Бюл. №2.
Association between metabolic syndrome and periodontal disease measures in postmenopausal women: the Buffalo OsteoPerio study / La Monte M.J., Williams A.M., Genco R.J. [et al. // J. Periodontol. – 2014. – Vol. 85, N 11. – P. 1489-1501 (МДА).
Биохимические маркеры воспаления тканей ротовой по-лости / [А. П. Левицкий, О. В. Деньга, О. А. Макаренко и др.]. // Методические рекомендации. – Одесса, 2010. – 16 с.
Ферментативный метод определения дисбиоза полости рта для скрининга про- и пребиотиков / [А. П. Левицкий, О. А. Ма-каренко, И. А. Селиванская и др.]. Методические рекомендации. – К.: ГФЦ, 2007. – 22 с.
