ODONTOGENIC MESENCHYMAL STEM CELLS: PROSPECTS AND POSSIBILITIES OF REGENERATIVE MEDICINE
DOI:
https://doi.org/10.35220/2078-8916-2021-41-3.6Keywords:
regenerative medicine, regenerative dentistry, stem cells, dental mesenchymal stem cells, tissue engineeringAbstract
Objective: To analyze the literature in the direction of scientific-theoretical and clinical aspects of the possibilities of using mesenchymal stem cells obtained from different sources of the maxillofacial area. Research methods: In the course of the research the bibliosemantic method and structural-logical analysis were used. A literature search was done using electronic databases PubMed, MEDLINE, Scopus, Web of Science and EMBASE by keywords “regenerative medicine”, “regenerative dentistry”, “stem cells”, “dental mesenchymal stem cells”, “stem cell therapy”. “tissue engineering”. Conclusions: Based on the analysis of the literature, there is a great interest of scientists in dental stem cells and their use in regenerative practice, not only for dental purposes, but also for the treatment of somatic diseases of various origins. This is due to the non-invasive and simpler method of material collection, compared to human bone marrow or embryonic tissues. Stem cells differ in origin, differential activity and source, and have a significant potential for differentiation in the direction of different cell lines depending on the influence of growth factors and nutrient medium. After obtaining new pure cultures, it is possible to establish their origin by identifying the expression of distinctive markers of stem cells. However, despite the high expectations from the further development of regenerative therapy, scientists need to study deeper the possibilities of using these cells in the clinical trial, to investigate the immunological behavior of stem cells of odontogenic origin in varied environments.
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