BIOCHEMICAL PARAMETERS OF RAT GUMS IN EXPERIMENTAL MODELING OF PERIODONTITIS AGAINST THE BACKGROUND OF ALIMENTARY VITAMIN D DEFICIENCY
DOI:
https://doi.org/10.35220/2078-8916-2023-49-3.1Keywords:
experiment, rats, vitamin D deficiency, periodontitis, biochemical parametersAbstract
Vitamin D deficiency and insufficiency is now regarded as a global problem. An alarming situation was found in children: the normal content of vitamin D was recorded only in 1.4 % of the examined, in 92.2 % it turned out to be a pronounced deficiency. Vitamin D regulation of phosphorus-calcium metabolism and bone tissue metabolism, as well as anti-inflammatory and immunomodulatory effects, influence on cell proliferation and differentiation can have a significant impact on the state of the oral cavity, causing in particular the development of periodontal diseases. The development of a complex for supporting the treatment of dental diseases in children against the background of vitamin D deficiency is an urgent task of modern stomatology. Purpose of the study. Experimental assessment on rats, against the background of a model of alimentary vitamin D deficiency, changes in biochemical indicators of gums under the effect of developed therapeutic and preventive measures. Materials and methods of research. In the experimental work, the following drugs were used: Mumiyo gel (Ukraine, Ukraine), "Strong teeth" (VTP Pharmakom, Ukraine), Aquadetrim vitamin D3 (Medana Pharma S.A., Poland). The study was conducted on 36 white Wistar rats of both sexes (1 month, weight 100±5 g), which were divided into 3 groups. The STATISTICA 6.1 computer program was used for statistical processing of the obtained results. to assess their reliability and measurement errors. Conclusions. In conditions of dietary deficiency of vitamin D, there are intensive processes of systemic inflammation, activation of lipid peroxidation, as well as inflammation and increased contamination of opportunistic microbiota on the gums, a decrease in antimicrobial and antioxidant protection in the oral cavity of experimental rats. Prophylactic use of the proposed complex of drugs against the background of dietary vitamin D deficiency led to positive changes in the gums of animals. The proposed prophylactic complex effectively reduced the processes of inflammation, lipid peroxidation, the development of opportunistic microbiota, and stimulated nonspecific antimicrobial and antioxidant protection in the oral cavity.
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