IMMUNOLOGICAL PHENOTYPE OF PATIENTS WITH CHRONIC RECURRENT APHTHOUS STOMATITIS, BY INFLAMMATORY BIOMARKERS
DOI:
https://doi.org/10.35220/2078-8916-2024-54-4.13Keywords:
C-reactive protein (CRP), D-dimer, erythrocyte sedimentation rate (ESR), inflammation, biomarker, chronic recurrent aphthous stomatitisAbstract
The global prevalence of CRAS, wide age range, recurrent nature and reduced quality of life of patients have led to a large number of studies on the immunological response in CRAS. The aim of the study was to characterize the immunological phenotype by inflammatory biomarkers – levels of C-reactive protein, D-dimer and ESR at the patients with CRAS. Materials and Methods. The determination of inflammatory biomarkers in the blood serum – levels of C-reactive protein, D-dimer and erythrocyte sedimentation rate was performed at 53 patients with CRAS and at 22 healthy people who formed the control group. Results and Discussion. The average value of the C-reactive protein level in the control group is 3.31±0.11 mg/l. At patients with CRAS, the level of CRS elevation corresponded to the clinical picture of the disease. So, at a small type of aphthosis, the CRP level was 8.03±0.72 mg/l, at a large type of aphthosis – 11.08±1.12 mg/l. The level of D-dimer in the control group was 0.64±0.05 mg/l. In case of small aphthosis, the index was increased (3.21±0.12 mg/l), at patients with large aphthosis, the index exceeded the index of patients with small aphthosis by 1.66 times. The studied population of patients with CRAS showed that in the case of small aphthosis among women, the average ESR was 17.33±1.29 mm/h, among men – 12.67±0.98 mm/h. Accordingly, at patients with CRAS with aphthosis, the average values of the index at women and men were 28.17±2.11 mm/h, 23.14±2.09 and mm. Conclusion. The analysis of the immunological phenotype of patients with CRAS by inflammatory biomarkers – levels of C-reactive protein, D-dimer and ESR – showed an increase in the level of the studied parameters, which can affect the specific and nonspecific reactions of the acquired immune system
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