COMPARATIVE ANALYSIS OF METHODS OF ADMINISTERING CHONDROPROTECTIVE DRUGS IN LABORATORY ANIMALS
Keywords:
Laboratory animals (rats), chondroprotective drugs, route of administration of drugsAbstract
It is not possible to prove in a laboratory way the effectiveness of a combined method of administering chondroprotectors to the structures of the temporomandibular joint of a human being. In laboratory animals, the effectiveness of the combined method of administration of chondroprotectors has been proved without violating the integrity of joint structures, which allows further recommending this technique to patients with joint diseases and reveals the possibilities of further clinical studies on the 8hastetiveness of the combined method of administration of drugs in humans without violating the integrity of joints struc-tures.
A comparative analysis of different ways of introducing chondroprotectors into the knee joint in laboratory animals was performed.
25 sexually mature, outbred, eight-month male rats served as a material for the experimental study performed. Before the exper-iment began, the animals were divided into 5 groups; each group consisted of five rats. The left knee joint was selected for the experimental observation.
Based on the analysis of the results of the study, the maximum optical density of the knee joint homogenates was obtained in the first and second groups. In these groups, parenteral admin-istration of Sinarta was performed, as well as additional rub-bing of chondroxide gel in the first group and electrophoresis with chondroxide gel in the second group.
Reliable differences in the effects were obtained when using dif-ferent methods of administering chondroprotective medicinal substances on joint structures. The most effective way of accu-mulation of glucosamine within the joints is a combination of in-tramuscular administration of the drug and topical administra-tion by rubbing or electrophoresis. The digital values of the op-tical density of joints homogenates indicate the effectiveness of the cumulative method of administering glucosamines and chondroitin sulfates into the structures of joints.
References
Эвтаназия экспериментальных животных (методические рекомендации по выведению животных из эксперимента). М.: Нау-ка. – 1985. – 32 с.
Остеоартроз: консервативная терапия: Монография / Авт. Кол.: А. Н. Хвистюк, Н. В. Дедух [и др.]; Под ред. Н. А. Коржа, Н. В. Дедух, И. А. Зупанца. – Харьков: Золотые страницы, – 2007. – 424 с.
Кляйнрок М. Функциональные нарушение двигательной части жевательного аппарата / Кляйнрок М. – Львов: «ГалДент». – 2015. – 256 с.
Семенов К. А. Клинический пример лечения пациента с хроническим травматическим артритом височно−нижнечелюстного сустава. / Семенов К. А. // Вісник стоматології. – 2016. − № 4. – С. 21−24.
Семенов К. А. Алгоритм ведения пациентов при хрониче-ском травматическом артрите височно-нижнечелюстного сустава / К. А. Семенов // Клінічна хірургія. – 2017. −№5 (901). – С. 52−55.
Семенов К.А. Роль генетических исследований в диагно-стике заболеваний височно – нижнечелюстного сустава / К.А. Се-менов, О. В. Деньга, В.Н. Горохивский // Клінічна хірургія. – 2018. – № 5.– С. 51-54.
