EXPERIMENTAL ASSESSMENT OF HEMATOLOGICAL PARAMETERS IN PERIPHERAL BLOOD OF RATS IN THE CONTEXT OF PEROXIDEINDUCED PERIODONTITIS, DIETARY PROTEIN DEFICIENCY, AND THERAPEUTIC AND PREVENTIVE MEASURES

Abstract

and nutritional protein deficiency, is a serious problem that can lead to significant disorders of dental health and general health. The relationship between periodontitis, osteopenia and osteoporosis emphasizes the need for an in-depth study of the impact of these pathologies on hematological parameters and the search for effective treatment and prevention measures. The purpose of the study was to experimentally evaluate hematological parameters in the peripheral blood of rats under conditions of modeling peroxidative periodontitis and nutritional protein deficiency, as well as to determine the effect of the treatment and prevention complex on these parameters. Materials and methods. The study used 30 Wistar rats, which were divided into three groups: an intact group, a group with a model of cumulative pathology, and a group with pathology that received the treatment complex. The model of cumulative pathology was created by introducing a low-protein diet and peroxidized sunflower oil. The treatment complex was used for a specified period. After the experiment, hematological parameters of peripheral blood were analyzed. Research results. In rats with a model of combined pathology, signs of inflammation were found, which was reflected in changes in hematological parameters, in particular, an increase in the number of leukocytes and a decrease in hemoglobin levels. The use of the therapeutic and prophylactic complex contributed to the normalization of these indicators, which indicates its positive effect on the hematopoietic system and the general condition of the body. Conclusions. The obtained results confirm the effectiveness of the treatment and prevention complex in the correction of hematologic disorders caused by peroxide periodontitis and protein deficiency. This indicates the prospects of using this approach to improve the dental health of patients with osteopenia and osteoporosis and may contribute to the development of new methods of prevention and treatment.