EXPERIMENTAL EVALUATION OF THE EFFECT OF THE THERAPEUTIC AND PROPHYLACTIC COMPLEX ON ATROPHY OF ALVEOLAR BONE AND DEVELOPMENT OF CARIES PROCESS IN RATS UNDER PESTICIDE LOAD
DOI:
https://doi.org/10.35220/2078-8916-2024-53-3.4Keywords:
pesticide load, bone, rats, experiment, biochemical markers.Abstract
Pesticide exposure, particularly the use of α-cypermethrin, negatively affects the condition of the dentoalveolar system, causing bone tissue resorption and the development of carious processes. This emphasizes the need to develop effective therapeutic and preventive measures to prevent these disorders. The purpose of the study was to evaluate the effect of a therapeutic complex of drugs on the degree of alveolar bone atrophy of the jaws and the development of carious processes in rats under conditions of pesticide load modeling. Materials and methods. The study involved 40 one-month-old Wistar rats. The animals were divided into five groups: intact group; group with a cariesogenic diet; group receiving the pesticide α-cypermethrin; group with a cariesogenic diet and pesticide; group with a cariesogenic diet, pesticide, and prophylactic treatment. The pesticide was administered orally at a dose of 10 mg/kg daily for 2 months. The degree of alveolar bone atrophy, the number of carious cavities, and their depth were assessed using standard methods. Research results. Prolonged pesticide exposure to α-cypermethrin led to significant atrophy of the alveolar bone of the jaws and intensified carious processes in rats, especially when combined with a cariesogenic diet. The use of a therapeutic and prophylactic complex of drugs effectively prevented the development of resorptive processes in the bone tissue and reduced the intensity of carious lesions to the level of intact animals. Conclusions. The therapeutic and prophylactic complex of drugs effectively reduces the negative impact of pesticide exposure and a cariesogenic diet on the dentoalveolar system, normalizing the state of bone tissue and preventing the development of caries. This confirms the expediency of using this complex to protect the dentoalveolar system under the influence of harmful factors.
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