DYNAMICS OF ORAL FLUID INDICATORS FOLLOWING SIALOSIS TREATMENT IN PATIENTS WITH HYPOTHYROIDISM

Abstract

Purpose of the study. To identify changes in oral fluid indicators after the treatment of sialosis in patients with hypothyroidism. Research methods. Based on the results of a comprehensive examination of 73 patients with hypothyroidism, 7 individuals were found to have the initial stage of sialosis, 57 had the clinically manifested stage, and 9 had the late stage. Mild pain in the areas of the salivary glands was reported by 25 patients, while the remaining patients did not note any discomfort or pain in these areas. Further study was conducted on the 57 patients who had a clinically manifested stage of sialosis on the background of hypothyroidism. These patients were divided into three groups. The first group included 17 individuals who were administered a 1% pilocarpine hydrochloride solution, 4 drops 1–2 times a day. In the second group of 19 individuals, general tonic therapy (AEvit + Vitamin C) was used in combination with physiotherapeutic procedures: ultrasound application of propolis oil in the parotid salivary gland areas. Ultraphonophoresis with propolis oil was performed using an ultrasonic therapy device. The third (control) group consisted of 21 individuals who received general tonic therapy (AEvit + Vitamin C). Scientific novelty. Our proposed therapeutic and prophylactic regimen – comprising a vitamin complex for general treatment and ultraphonophoresis with propolis oil as a local treatment for sialosis in patients with hypothyroidism – leads to a significant improvement in the condition of the oral cavity. It reduces the size of the salivary glands, decreases inflammation, alleviates dryness of the vermilion border of the lips, eliminates fissures and angular cheilitis, and reduces the size of regional lymph nodes. Conclusions. Examination of the total protein concentration in the oral fluid of patients with sialosis on the background of hypothyroidism showed elevated levels in all groups at the beginning of the study. Investigation of alkaline phosphatase activity prior to treatment in patients with sialosis and hypothyroidism demonstrated an increased level in all study groups, averaging 0,34 ± 0,017. The data provided indicate that in patients with sialosis associated with hypothyroidism, the oral fluid viscosity remains at a sufficiently high level, which may be a significant factor predisposing to a cariogenic situation and leading to gingival inflammation in the oral cavity.