EFFICIENCY OF DIFFERENTIATED IMMUNO-CORRECTIVE THERAPY IN THE TREATMENT OF PERI-IMPLANT MUCOSITIS
DOI:
https://doi.org/10.35220/2078-8916-2024-54-4.15Keywords:
peri-implant mucositis, immunomodulatory therapy, immunological disorders, laboratory tests for predicting the outcome of immunomodulatory therapyAbstract
Among the most important problems of Modern Dentistry, the fight against inflammatory complications of dental implantation occupies one of the leading places. As you
know, peri-implant mucositis, unfortunately, is a very common pathology and the main cause of the development of peri-implantitis, and subsequently the loss of a dental implant in people of middle and older age groups of the population, which requires increased attention of researchers to the problem of etiology, pathogenesis, diagnosis and therapy of this disease. The analysis of the data presented in the literature allows us to conclude that even today immunomodulators are most often used in Implantology undifferentiated, without taking into account the depth of immunodeficiency, without a clear assessment of the effectiveness of drugs, etc. Purpose of the study. To develop tactics of differentiated immunocorrective therapy in the treatment of periimplant mucositis, taking into account the initial characteristics of the immune status of patients. Materials and methods of research. The study included 76 patients with periimplant mucositis: 37 women and 39 men. The mean age of patients was 39.6±2.7 years. To determine the norm during clinical and laboratory research methods, 26 practically healthy people of the same age and gender without periodontal pathology with sanitized teeth were selected. The condition of periimplant and periodontal tissues was assessed on the basis of generally accepted clinical and paraclinical tests. Conclusions. Based on clinical and immunological studies and the results of complex treatment of patients with peri-implant mucositis, it has been established that the most promising for the correction of immunological disorders are cycloferon and polyoxidonium. As an immunomodulatory agent, cycloferon is recommended for mild cases of the disease, and polyoxidonium for severe (progressive) manifestations of the pathological process in peri-implant tissues. The differentiated use of cycloferon and Polyoxidonium in patients with peri-implant mucositis helps to reduce treatment time and increase the overall effectiveness of antibacterial therapy. The necessity of using a laboratory test for determining the intercellular adhesion molecule in blood serum is argued to assess the severity of peri-implant mucositis and predict the effectiveness of various immunocorrective agents.
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